Active mechanism
How do omega-3s work?
Polyunsaturated fatty acids form part of the structure of the cell membranes, which are barriers with highly-selective permeability. These membranes are involved in the energy-transformation process, regulate the information flows between cells and contain receptors sensitive to external stimuli.
| Omega-3 acids (EPA, DHA) and omega-6 acids (arachidonic acid) are constituents of the double layer of phospholipids that make up the cell membranes. |
The particular configuration of the double bonds in polyunsaturated fatty acids gives them physical properties approaching those of a fluid. Long-chain polyunsaturated fatty acids thus ensure the flexibility of the biological membranes.
They also play a role as messengers. Long-chain fatty acids are precursors for eicosanoids including prostaglandins and leukotrienes. Eicosanoids behave like local hormones and regulate cell functions.
| As eicosanoids, polyunsaturated fatty acids play a part in the inflammatory process, in regulating blood flow, in controlling ion transport and in modulating synaptic transmission. Omega-3 and omega-6 eicosanoids often have opposing effects. Omega-6 promotes aggregation and inflammation, while omega-3 has the opposite, anti-aggregation and anti-inflammatory effect. |


